Rho GTPase function in tumorigenesis.

  title={Rho GTPase function in tumorigenesis.},
  author={Richard Karlsson and Elena Didenko Pedersen and Zhe Wang and Cord Brakebusch},
  journal={Biochimica et biophysica acta},
  volume={1796 2},
Malignant tumor cells display uncontrolled proliferation, loss of epithelial cell polarity, altered interactions with neighboring cells and the surrounding extracellular matrix, and enhanced migratory properties. Proteins of the Rho GTPase family regulate all these processes in cell culture and, for that reason, Rho GTPases, their regulators, and their effectors have been suggested to control tumor formation and progression in humans. However, while the tumor-relevant functions of Rho GTPases… CONTINUE READING