Rho-GTPase-activating Protein Interacting with Cdc-42-interacting Protein 4 Homolog 2 (Rich2)

  title={Rho-GTPase-activating Protein Interacting with Cdc-42-interacting Protein 4 Homolog 2 (Rich2)},
  author={F. Raynaud and E. Moutin and S. Schmidt and J. Dahl and F. Bertaso and T. Boeckers and V. Homburger and L. Fagni},
  journal={The Journal of Biological Chemistry},
  pages={2600 - 2609}
  • F. Raynaud, E. Moutin, +5 authors L. Fagni
  • Published 2013
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • Background: Rich2 is a synaptic Rho-GAP (Rho-GTPase-activating protein) the target of which was unknown. Results: We found that Rich2 controls dendritic spine morphogenesis by inhibiting Rac1 activity. Conclusion: Rac1 is the target of Rich2 in spines. Significance: We identified for the first time Rich2 as a Rac1-GAP protein that plays an important role in spine formation. Development of dendritic spines is important for synaptic function, and alteration in spine morphogenesis is often… CONTINUE READING
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