Rho-GTPase-activating Protein Interacting with Cdc-42-interacting Protein 4 Homolog 2 (Rich2)

@article{Raynaud2013RhoGTPaseactivatingPI,
  title={Rho-GTPase-activating Protein Interacting with Cdc-42-interacting Protein 4 Homolog 2 (Rich2)},
  author={F. Raynaud and E. Moutin and S. Schmidt and J. Dahl and F. Bertaso and T. Boeckers and V. Homburger and L. Fagni},
  journal={The Journal of Biological Chemistry},
  year={2013},
  volume={289},
  pages={2600 - 2609}
}
  • F. Raynaud, E. Moutin, +5 authors L. Fagni
  • Published 2013
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • Background: Rich2 is a synaptic Rho-GAP (Rho-GTPase-activating protein) the target of which was unknown. Results: We found that Rich2 controls dendritic spine morphogenesis by inhibiting Rac1 activity. Conclusion: Rac1 is the target of Rich2 in spines. Significance: We identified for the first time Rich2 as a Rac1-GAP protein that plays an important role in spine formation. Development of dendritic spines is important for synaptic function, and alteration in spine morphogenesis is often… CONTINUE READING
    24 Citations
    Modulation of actin dynamics by Rac1 to target cognitive function
    • 34
    A dual role for the RhoGEF Ephexin5 in regulation of dendritic spine outgrowth
    • 8
    • Highly Influenced
    BAR domain proteins regulate Rho GTPase signaling
    • 24
    Stress-Sensitive Protein Rac1 and Its Involvement in Neurodevelopmental Disorders
    Rho GTPases in Intellectual Disability: From Genetics to Therapeutic Opportunities
    • 24
    • PDF

    References

    SHOWING 1-10 OF 29 REFERENCES
    RICH, a Rho GTPase-activating Protein Domain-containing Protein Involved in Signaling by Cdc42 and Rac1*
    • 117
    • PDF
    The PAR-6 polarity protein regulates dendritic spine morphogenesis through p190 RhoGAP and the Rho GTPase.
    • 146
    • PDF
    Synapse formation is regulated by the signaling adaptor GIT1
    • 200
    • PDF
    Shank3-Rich2 Interaction Regulates AMPA Receptor Recycling and Synaptic Long-Term Potentiation
    • 44
    • PDF
    Role of numb in dendritic spine development with a Cdc42 GEF intersectin and EphB2.
    • 114
    • PDF
    Control of synapse development and plasticity by Rho GTPase regulatory proteins
    • 202