Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells.

@article{Ming2002RhoGK,
  title={Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells.},
  author={X Y Ming and Hema Viswambharan and Christine Barandier and Jean Ruffieux and Kozo Kaibuchi and Sandro Rusconi and Zhihong Yang},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 24},
  pages={8467-77}
}
Endothelial nitric oxide synthase (eNOS) is an important regulator of cardiovascular homeostasis by production of nitric oxide (NO) from vascular endothelial cells. It can be activated by protein kinase B (PKB)/Akt via phosphorylation at Ser-1177. We are interested in the role of Rho GTPase/Rho kinase (ROCK) pathway in regulation of eNOS expression and activation. Using adenovirus-mediated gene transfer in human umbilical vein endothelial cells (HUVECs), we show here that both active RhoA and… CONTINUE READING

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