Rho‐specific binding and guanine nucleotide exchange catalysis by KIAA0380, a Dbl family member

  title={Rho‐specific binding and guanine nucleotide exchange catalysis by KIAA0380, a Dbl family member},
  author={U. R{\"u}menapp and A. Blomquist and G. Schwoerer and H. Schablowski and A. Psoma and K. Jakobs},
  journal={FEBS Letters},
  • U. Rümenapp, A. Blomquist, +3 authors K. Jakobs
  • Published 1999
  • Medicine, Biology
  • FEBS Letters
  • Several guanine nucleotide exchange factors (GEFs) for Rho‐GTPases have been identified, all of them containing a Dbl homology (DH) and pleckstrin homology (PH) domain, but exhibiting different specificities to the Rho family members, Rho, Rac and Cdc42. We report here that KIAA0380, a protein with a tandem DH/PH domain, an amino‐terminal PDZ domain and a regulator of G protein signalling (RGS) homology domain, is a specific GEF for RhoA, but not for Rac1 and Cdc42, as determined by GDP release… CONTINUE READING
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