Rho/Rho-associated kinase pathway in glaucoma (Review).

@article{Wang2013RhoRhoassociatedKP,
  title={Rho/Rho-associated kinase pathway in glaucoma (Review).},
  author={Jing Wang and Xiaohong Liu and Yisheng Zhong},
  journal={International journal of oncology},
  year={2013},
  volume={43 5},
  pages={1357-67}
}
The Rho/ROCK pathway plays important roles in the modulation of the cytoskeletal integrity of cells, the synthesis of extracellular matrix components in the aqueous humor outflow tissue and the permeability of Schlemm's canal endothelial cells. The activation of the Rho/ROCK pathway results in trabecular meshwork (TM) contraction, and the inhibition of this pathway would provoke relaxation of TM with subsequent increase in outflow facility and, thereby, decrease intraocular pressure (IOP). ROCK… CONTINUE READING
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