Rhizocticin A, an antifungal phosphono-oligopeptide of Bacillus subtilis ATCC 6633: biological properties

@article{Kugler2004RhizocticinAA,
  title={Rhizocticin A, an antifungal phosphono-oligopeptide of Bacillus subtilis ATCC 6633: biological properties},
  author={Martin Kugler and Wolfgang Loeffler and Claudius Rapp and Armin Kern and G Jung},
  journal={Archives of Microbiology},
  year={2004},
  volume={153},
  pages={276-281}
}
Rhizocticin A, the main component of the antifungal, hydrophilic phosphono-oligopeptides of Bacillus subtilis ATCC 6633, was used for sensitivity testing and experiments into the molecular mechanism of the antibiotic action. Budding and filamentous fungi as well as the cultivated nematode Caenorhabditis elegans were found to be sensitive, whereas bacteria and the protozoon Paramecium caudatum were insensitive. Rhizoctonia solani was inhibited in agar dilution tests but not in diffusion tests… 
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This work establishes the self-resistance mechanism utilized by B. subtilis ATCC 6633 against APPA, exemplifying one of many ways by which bacteria can overcome phosphonate toxicity.
Diversity and applications of Bacillus bacteriocins.
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The present review provides a general overview of Bacillus bacteriocins, including primary structure, biochemical and genetic characterization, classification and potential applications in food preservation as natural preservatives and in human and animal health as alternatives to conventional antibiotics.
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Synthesis and biological evaluation of potential threonine synthase inhibitors: Rhizocticin A and Plumbemycin A.
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The chemical stereoselective synthesis of the non-proteinogenic (S,Z)-2-amino-5-phosphonopent-3-enoic acid [(S, Z)-APPA] and its use for the synthesis of Rhizocticin A and Plumbemycin A is reported.
Identification of Antifungal Substance (Iturin A2) Produced by Bacillus subtilis B47 and Its Effect on Southern Corn Leaf Blight
Bacillus subtilis B47 is an endophytic bacterium of tomato, and produces substance that strongly inhibits the growth of Bipolaris maydis, the pathogen of southern corn leaf blight (SCLB), as well as
Mycosubtilin Overproduction by Bacillus subtilis BBG100 Enhances the Organism's Antagonistic and Biocontrol Activities
ABSTRACT A Bacillus subtilis derivative was obtained from strain ATCC 6633 by replacement of the native promoter of the mycosubtilin operon by a constitutive promoter originating from the replication
Bacillus subtilis antibiotics: structures, syntheses and specific functions
  • T. Stein
  • Biology, Medicine
    Molecular microbiology
  • 2005
TLDR
The structures of all known B. subtilis antibiotics are summarized, including non‐ribosomally produced lipopeptides are involved in biofilm and swarming development, lantibiotics function as pheromones in quorum‐sensing, and a ‘killing factor’ effectuates programmed cell death in sister cells.
Temperature dependence of mycosubtilin homologue production in Bacillus subtilis ATCC6633.
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