Rhinovirus replication in human macrophages induces NF-kappaB-dependent tumor necrosis factor alpha production.

@article{LazaStanca2006RhinovirusRI,
  title={Rhinovirus replication in human macrophages induces NF-kappaB-dependent tumor necrosis factor alpha production.},
  author={Vasile Laza-Stanca and Luminita A. Stanciu and Simon D. Message and Michael J. Edwards and James E Gern and Sebastian L Johnston},
  journal={Journal of virology},
  year={2006},
  volume={80 16},
  pages={8248-58}
}
Rhinoviruses (RV) are the major cause of acute exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Rhinoviruses have been shown to activate macrophages, but rhinovirus replication in macrophages has not been reported. Tumor necrosis factor alpha (TNF-alpha) is implicated in the pathogenesis of acute exacerbations, but its cellular source and mechanisms of induction by virus infection are unclear. We hypothesized that rhinovirus replication in human macrophages causes… CONTINUE READING
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