Rhinovirus-induced interferon production is not deficient in well controlled asthma.

  title={Rhinovirus-induced interferon production is not deficient in well controlled asthma.},
  author={Annemarie Sykes and Jonathan D. R. Macintyre and Michael J. Edwards and Ajerico del Rosario and Jennifer J. Haas and V. M. Gielen and Onn Min Kon and Mark T McHale and Sebastian L Johnston},
  volume={69 3},
BACKGROUND Defective rhinovirus (RV)-induced interferon (IFN)-β and IFN-λ production and increased RV replication have been reported in primary human bronchial epithelial cells (HBECs) from subjects with asthma. How universal this defect is in asthma is unknown. Additionally, the IFN subtypes induced by RV infection in primary HBECs have not been comprehensively investigated. OBJECTIVE To study RV induction of IFN-α, IFN-β and IFN-λ and RV replication in HBECs from subjects with atopic asthma… CONTINUE READING
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Rhinovirus 16induced IFNalpha and IFNbeta are de fi cient in bronchoalveolar lavage cells in asthmatic patients

  • A Sykes, MR Edwards, J Macintyre
  • J Allergy Clin Immunol
  • 2012

Toll - like receptor 7 function is reduced in adolescents with asthma

  • MR Edwards, N Regamey, M Vareille
  • Eur Respir J
  • 2010

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