Rhinovirus increases human beta-defensin-2 and -3 mRNA expression in cultured bronchial epithelial cells.

@article{Duits2003RhinovirusIH,
  title={Rhinovirus increases human beta-defensin-2 and -3 mRNA expression in cultured bronchial epithelial cells.},
  author={Louise A Duits and Peter H Nibbering and Elisabeth van Strijen and Joost B. Vos and Sylvia P G Mannesse-Lazeroms and Marianne A J A van Sterkenburg and Pieter S Hiemstra},
  journal={FEMS immunology and medical microbiology},
  year={2003},
  volume={38 1},
  pages={59-64}
}
Human beta-defensins (hBDs) are antimicrobial peptides that play important roles in host defense against infection, inflammation and immunity. Previous studies showed that micro-organisms and proinflammatory mediators regulate the expression of these peptides in airway epithelial cells. The aim of the present study was to investigate the modulation of expression of hBDs in cultured primary bronchial epithelial cells (PBEC) by rhinovirus-16 (RV16), a respiratory virus responsible for the common… CONTINUE READING