Rhinovirus Genome Evolution during Experimental Human Infection

  title={Rhinovirus Genome Evolution during Experimental Human Infection},
  author={Samuel Cordey and Thomas Junier and Daniel Gerlach and Francesca Gobbini and Laurent Farinelli and Evgeny M. Zdobnov and Birgit Winther and Caroline Tapparel and Laurent Kaiser},
  booktitle={PloS one},
Human rhinoviruses (HRVs) evolve rapidly due in part to their error-prone RNA polymerase. Knowledge of the diversity of HRV populations emerging during the course of a natural infection is essential and represents a basis for the design of future potential vaccines and antiviral drugs. To evaluate HRV evolution in humans, nasal wash samples were collected daily for five days from 15 immunocompetent volunteers experimentally infected with a reference stock of HRV-39. In parallel, HeLa-OH cells… CONTINUE READING