Rheumatoid lung nodulosis and osteopathy associated with leflunomide therapy

@article{Rozin2005RheumatoidLN,
  title={Rheumatoid lung nodulosis and osteopathy associated with leflunomide therapy},
  author={Alexander P Rozin and Mordechai Yigla and Luda Guralnik and Zohar Keidar and Euvgeni Vlodavsky and Michael Rozenbaum and Abraham Menahem Nahir and Alexandra Balbir-Gurman},
  journal={Clinical Rheumatology},
  year={2005},
  volume={25},
  pages={384-388}
}
BackgroundLeflunomide (LEF) is indicated in adults for the treatment of active rheumatoid arthritis (RA). LEF inhibits dehydroorotate dehydrogenase, a key enzyme of the pyrimidine synthesis in activated lymphocytes. Among rare adverse effects, fatal interstitial lung disease has been recently reported during treatment of RA with LEF in Japan. Clinical trials outside Japan do not suggest that LEF causes an excess of pulmonary adverse effects. Development and increase of peripheral rheumatoid… 
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TLDR
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TLDR
A 74-year-old male with long-standing rheumatoid arthritis who had multiple cavitating lung nodules was empirically treated with a moderate dose of glucocorticoid along with conventional synthetic disease-modifying antirheumatic drugs and his articular symptoms showed marked improvement.
Accelerated pulmonary nodulosis and sterile pleural effusion in a patient with psoriatic arthropathy during methotrexate therapy: a case report.
TLDR
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The effect of disease modifying drugs on the lung in patients with rheumatoid arthritis
TLDR
In this review, the association between methotrexate, leflunomide, and newer biologic agents and lung disease in patients with rheumatoid arthritis is evaluated.
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