Rheumatoid fibroblast-like synoviocytes overexpress the chemokine stromal cell-derived factor 1 (CXCL12), which supports distinct patterns and rates of CD4+ and CD8+ T cell migration within synovial tissue.

@article{Bradfield2003RheumatoidFS,
  title={Rheumatoid fibroblast-like synoviocytes overexpress the chemokine stromal cell-derived factor 1 (CXCL12), which supports distinct patterns and rates of CD4+ and CD8+ T cell migration within synovial tissue.},
  author={Paul F. Bradfield and Nicole Amft and Elizabeth Vernon-Wilson and Andrew Exley and Greg N. Parsonage and G Ed Rainger and Gerard B Nash and Andrew M C Thomas and David Ll. Simmons and Mike Salmon and Christopher D Buckley},
  journal={Arthritis and rheumatism},
  year={2003},
  volume={48 9},
  pages={2472-82}
}
OBJECTIVE A characteristic feature of the inflammatory infiltrate in rheumatoid arthritis is the segregation of CD4 and CD8 T lymphocyte subsets into distinct microdomains within the inflamed synovium. The aim of this study was to test the hypothesis that chemokines in general and stromal cell-derived factor 1 (SDF-1; CXCL12) in particular are responsible for generating this distinctive microcompartmentalization. METHODS We examined how synovial CD4/CD8 T cell subsets interacted in coculture… CONTINUE READING
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