Rheumatoid factor.

  title={Rheumatoid factor.},
  author={Pojen P. Chen and S Fong and Dennis A. Carson},
  journal={Rheumatic diseases clinics of North America},
  volume={13 3},
Many human RF-associated crossreactive idiotypes (CRIs) have been defined. Since these CRIs probably are the phenotypic markers of Ig variable region genes, the data suggest that human RFs employ several Ig variable region genes which are common among outbred human populations. There are at least four types of stimuli which can trigger RF production. They are aggregated IgG in the form of antigen-antibody complexes, exogenous antigens bearing cross-reactive determinants to human IgG, autologous… CONTINUE READING