Rheumatoid arthritis synovium contains plasmacytoid dendritic cells

  title={Rheumatoid arthritis synovium contains plasmacytoid dendritic cells},
  author={Lois L. Cavanagh and Amanda Boyce and Louise Lawson Smith and Jagadish Padmanabha and Luis Filgueira and Peter Pietschmann and Ranjeny Thomas},
  journal={Arthritis Research & Therapy},
  pages={R230 - R240}
We have previously described enrichment of antigen-presenting HLA-DR+ nuclear RelB+ dendritic cells (DCs) in rheumatoid arthritis (RA) synovium. CD123+HLA-DR+ plasmacytoid DCs (pDCs) and their precursors have been identified in human peripheral blood (PB), lymphoid tissue, and some inflamed tissues. We hypothesized recruitment of pDCs into the inflamed RA synovial environment and their contribution as antigen-presenting cells (APCs) and inflammatory cells in RA. CD11c+ myeloid DCs and CD123… CONTINUE READING


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Functional CD40 ligand is expressed by T cells in rheumatoid arthritis.

The Journal of clinical investigation • 1997
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