Rheumatoid arthritis following a treatment with IFN-alpha/ribavirin against HCV infection.

  title={Rheumatoid arthritis following a treatment with IFN-alpha/ribavirin against HCV infection.},
  author={Yasumori Izumi and Atsumasa Komori and Yuki Yasunaga and Satoru Hashimoto and Taiichiro Miyashita and Seigo Abiru and Hiroshi Yatsuhashi and Hiromi Ishibashi and Kiyoshi Migita},
  journal={Internal medicine},
  volume={50 9},
We report a 48-year-old man who developed rheumatoid arthritis (RA) after a successful treatment with peg-IFN-alpha plus ribavirin for chronic hepatitis C virus (HCV) infection. He had a history of smoking and a single copy of the HLA-DRB1 shared epitope (SE). In a retrospective analysis, he exhibited the anti-CCP antibodies before the start of IFN plus ribavirin treatment. However, the titers of anti-CCP antibodies and BAFF levels were elevated by the IFN plus ribavirin therapy. These… CONTINUE READING
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