Rheumatoid arthritis association at 6q23

  title={Rheumatoid arthritis association at 6q23},
  author={Wendy Thomson and Anne Barton and Xiayi Ke and Stephen Eyre and Anne Hinks and John Bowes and Rachelle P. Donn and Deborah P. M. Symmons and Samantha L Hider and Ian N. Bruce and Anthony G. Wilson and Ioanna Marinou and Ann W Morgan and Paul Emery and Angela M. Carter and Sophia Steer and Lynne J. Hocking and David M. Reid and Paul Wordsworth and Pille Harrison and David Strachan and Jane Worthington},
  journal={Nature Genetics},
The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 × 10−5 − 5 × 10−7 in a genome-wide association screen. One, rs6920220, was unequivocally replicated (trend P = 1.1 × 10−8) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-α–induced protein 3 (TNFAIP3).