Rheumatoid arthritis as a hyper-endoplasmic reticulum-associated degradation disease

@article{Yamasaki2005RheumatoidAA,
  title={Rheumatoid arthritis as a hyper-endoplasmic reticulum-associated degradation disease},
  author={Satoshi Yamasaki and Naoko Yagishita and Kaneyuki Tsuchimochi and Kusuki Nishioka and Toshihiro Nakajima},
  journal={Arthritis Research & Therapy},
  year={2005},
  volume={7},
  pages={181 - 186}
}
We introduce Synoviolin as a novel pathogenic factor in rheumatoid arthritis (RA). Experimental studies indicate that this endoplasmic reticulum (ER)-resident E3 ubiquitin ligase has important functions in the ER-associated degradation (ERAD) system, an essential system for ER homeostasis. Overexpression of Synoviolin in mice causes arthropathy with synovial hyperplasia, whereas heterozygous knockdown results in increased apoptosis of synovial cells and resistance to collagen-induced arthritis… CONTINUE READING

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