Rheumatoid arthritis: Are ACPA-positive and ACPA-negative RA the same disease?

@article{Daha2011RheumatoidAA,
  title={Rheumatoid arthritis: Are ACPA-positive and ACPA-negative RA the same disease?},
  author={Nina A. Daha and Ren{\'e} E M Toes},
  journal={Nature Reviews Rheumatology},
  year={2011},
  volume={7},
  pages={202-203}
}
Seemingly contrasting genetic backgrounds in anti-citrullinated-protein antibody (ACPA)-positive and ACPA-negative rheumatoid arthritis (RA) support the notion that these are in fact two distinct disease subsets, with different underlying pathogenesis, that might need tailored treatment strategies. 

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