Rheumatoid arthritis, Proteus, anti-CCP antibodies and Karl Popper.

  title={Rheumatoid arthritis, Proteus, anti-CCP antibodies and Karl Popper.},
  author={Alan Ebringer and Taha Rashid and Clyde D Wilson},
  journal={Autoimmunity reviews},
  volume={9 4},
Rheumatoid arthritis (RA) is a crippling joint disease affecting over 20 million people worldwide. The cause of RA is most probably linked to the triad of microbial trigger, genetic association and autoimmunity and can be explained using the philosophical method of Karl Popper or Popperian sequences. Ten "Popper sequences" have been identified which point to the urinary microbe Proteus mirabilis as the cause of RA: Popper sequence 1 establishes that HLA-DR4 lymphocytes injected into a rabbit… CONTINUE READING
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