Rheumatic heart disease

@article{Marijon2012RheumaticHD,
  title={Rheumatic heart disease},
  author={E. Marijon and M. Mirabel and D. Celermajer and X. Jouven},
  journal={The Lancet},
  year={2012},
  volume={379},
  pages={953-964}
}
Rheumatic heart disease, often neglected by media and policy makers, is a major burden in developing countries where it causes most of the cardiovascular morbidity and mortality in young people, leading to about 250,000 deaths per year worldwide. The disease results from an abnormal autoimmune response to a group A streptococcal infection in a genetically susceptible host. Acute rheumatic fever--the precursor to rheumatic heart disease--can affect different organs and lead to irreversible valve… Expand

Paper Mentions

Observational Clinical Trial
FEVRIER study is an observatory of hospitalizations in cardiology units in sub-Saharan Africa.  
ConditionsAcute Coronary Syndrome, Conduction Abnormalities, Deep Vein Thrombosis, (+8 more)
InterventionOther
Observational Clinical Trial
This study will determine the prevalence of rheumatic heart disease (RHD) in Lusaka, Zambia through school-based screening methodology using ultraportable echocardiography and a… Expand
ConditionsRheumatic Heart Disease
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Current management strategies for valvular rheumatic heart disease are outlined on the basis of either strong evidence or expert consensus, and areas needing future research and development are highlighted. Expand
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Interleukin-10: Role in increasing susceptibility and pathogenesis of rheumatic fever/rheumatic heart disease.
TLDR
This review summarizes the studies based on association of interleukin-10 with RHD in different populations to understand the role of IL-10 in susceptibility and pathogenesis of the disease. Expand
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References

SHOWING 1-10 OF 141 REFERENCES
Is Primary Prevention of Rheumatic Fever the Missing Link in the Control of Rheumatic Heart Disease in Africa?
TLDR
It is argued that a strategy of primary antibiotic prophylaxis, with appropriate modifications, can be successfully implemented in resource-poor settings across the world and should be a key component of any rheumatic heart disease control program. Expand
Rheumatic and Nonrheumatic Valvular Heart Disease: Epidemiology, Management, and Prevention in Africa
TLDR
The spectrum and presentation of valvular disease in Africa are uniquely different from elsewhere, and this fact makes it imperative that further epidemiological and clinical studies be undertaken and guidelines developed that are appropriate to the practice of medicine on the African continent. Expand
Management of patients with subclinical rheumatic heart disease.
TLDR
Despite the apparent normal status, these children presented significant features of RHD at echocardiography, which clearly underestimated the burden of the disease since the cardiac auscultation used in these surveys was unable to detect early-stage RHD cases. Expand
Prevention and treatment of rheumatic heart disease in the developing world
TLDR
RHD will continue to cause high morbidity and mortality among the world's poorest populations unless current prevention initiatives expand and new programs are established. Expand
Echocardiographic screening for rheumatic heart disease.
TLDR
Both RF and RHD continue essentially unabated in many developing countries and in indigenous populations (such as that in Australia); in these settings, RHD remains an important and significant cause of morbidity and mortality. Expand
Rheumatic heart disease in indigenous populations.
TLDR
Involvement of Indigenous people in decision making, design, and implementation of primary and secondary prevention programs, is mandatory to reduce the unacceptably high rates of rheumatic heart disease. Expand
The Spectrum of Severe Rheumatic Mitral Valve Disease in a Developing Country: Correlations among Clinical Presentation, Surgical Pathologic Findings, and Hemodynamic Sequelae
Bland and Jones [1], in their benchmark report on rheumatic fever and rheumatic heart disease in 1951, documented a mortality rate of 50% by age 20 years among young patients presenting withExpand
Epidemiology and prevention of valvular heart diseases and infective endocarditis in Africa
TLDR
Combating and eradicating rheumatic fever and rhematic heart diseases requires economic development and implementation of best practices of primary and secondary prevention measures, and the barriers to achieving this goal are numerous, but not insurmountable. Expand
Rheumatic Fever and Rheumatic Heart Disease: Cellular Mechanisms Leading Autoimmune Reactivity and Disease
TLDR
Molecular mimicry is the mechanism that mediated the cross-reactions between streptococcal antigens and human proteins that leads to rheumatic heart disease. Expand
Cost-effective control of rheumatic fever in the community.
TLDR
A multi-centre study conducted by the WHO has shown that the cost of antibiotics used for secondary prevention was less than the savings resulting from the lower incidence and shorter hospital stays of recurrencies of rheumatic fever. Expand
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