Rhesus monkey model for concurrent analyses of in vivo selectivity, pharmacokinetics and pharmacodynamics of aldosterone synthase inhibitors.

@article{Cai2015RhesusMM,
  title={Rhesus monkey model for concurrent analyses of in vivo selectivity, pharmacokinetics and pharmacodynamics of aldosterone synthase inhibitors.},
  author={Tian-quan Cai and Sloan Stribling and Xinchun S Tong and Ling Xu and Thomas Wisniewski and Jane A Fontenot and Mary V Struthers and Karen O. Akinsanya},
  journal={Journal of pharmacological and toxicological methods},
  year={2015},
  volume={71},
  pages={137-46}
}
INTRODUCTION In vivo profiles of aldosterone synthase inhibitors (ASIs) have been investigated utilizing various rodent models. Due to lack of CYP17 activity, rodents produce corticosterone rather than cortisol as that of humans, which raised concern to their effectiveness in translational pharmacological characterization of ASI. METHODS A rhesus monkey… CONTINUE READING