Rhesus monkey TRIM5α restricts HIV-1 production through rapid degradation of viral Gag polyproteins

@article{Sakuma2007RhesusMT,
  title={Rhesus monkey TRIM5α restricts HIV-1 production through rapid degradation of viral Gag polyproteins},
  author={Ryuta Sakuma and Josh A. Noser and Seiga Ohmine and Yasuhiro Ikeda},
  journal={Nature Medicine},
  year={2007},
  volume={13},
  pages={631-635}
}
Mammalian cells have developed diverse strategies to restrict retroviral infection. Retroviruses have therefore evolved to counteract such restriction factors, in order to colonize their hosts. Tripartite motif-containing 5 isoform-α (TRIM5α) protein from rhesus monkey (TRIM5αrh) restricts human immunodeficiency virus type 1 (HIV-1) infection at a postentry, preintegration stage in the viral life cycle, by recognizing the incoming capsid and promoting its premature disassembly. TRIM5α comprises… CONTINUE READING
BETA

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 55 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 31 REFERENCES

a lesson in detente

  • A. Garcia-Sastre, Biron, C. A. Type 1 interferons, the virus-host relationship
  • Science 312, 879–882
  • 2006

Similar Papers

Loading similar papers…