Rhesus macaque and chimpanzee DC-SIGN act as HIV/SIV gp120 trans-receptors, similar to human DC-SIGN.

@article{Geijtenbeek2001RhesusMA,
  title={Rhesus macaque and chimpanzee DC-SIGN act as HIV/SIV gp120 trans-receptors, similar to human DC-SIGN.},
  author={Teunis B H Geijtenbeek and Gerrit Koopman and Gerard C.F. van Duijnhoven and Sandra J van Vliet and Alexandra van Schijndel and Anneke Engering and Jonathan Luke Heeney and Yvette van Kooyk},
  journal={Immunology letters},
  year={2001},
  volume={79 1-2},
  pages={101-7}
}
Dendritic cells (DC) have been implicated in the pathogenesis of both human and simian immunodeficiency viruses (HIV and SIV, respectively). The DC-specific HIV-1 trans-receptor DC-SIGN is thought to be essential for viral dissemination by DC. Abundant expression in lymphoid tissues also implies a function for DC-SIGN in chronic HIV-1 infections, in facilitating persistent infection of T cells. We have therefore isolated the rhesus macaque and chimpanzee homologues of DC-SIGN to investigate… CONTINUE READING