Rhesus enteric calicivirus surrogate model for human norovirus gastroenteritis.

@article{Farkas2015RhesusEC,
  title={Rhesus enteric calicivirus surrogate model for human norovirus gastroenteritis.},
  author={Tibor Farkas},
  journal={The Journal of general virology},
  year={2015},
  volume={96 Pt 7},
  pages={
          1504-14
        }
}
  • T. Farkas
  • Published 1 July 2015
  • Biology
  • The Journal of general virology
Human noroviruses are one of the major causes of acute gastroenteritis worldwide. Due to the lack of an efficient human norovirus cell culture system coupled with an animal model, human norovirus research mainly relies on human volunteer studies and surrogate models. Current models either utilize human norovirus-infected animals including the gnotobiotic pig or calf and the chimpanzee models, or employ other members of the family Caliciviridae including cell culture propagable surrogate… 

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References

SHOWING 1-10 OF 56 REFERENCES

Relationship between genotypes and serotypes of genogroup 1 recoviruses: a model for human norovirus antigenic diversity.

The newly developed ReCV surrogate model can be applied to address biologically relevant questions pertaining to enteric CV diversity, and imply the existence of a large number of human NoV serotypes, but also shared cross-neutralization epitopes between some strains of different genotypes.

A Mouse Model for Human Norovirus

HuNoV replication in BALB/c Rag-γc-deficient mice provides the first genetically manipulable small-animal model for studying HuNoV infection and will accelerate the understanding of human norovirus biology and provide a useful resource for evaluating antiviral therapies.

Comprehensive Comparison of Cultivable Norovirus Surrogates in Response to Different Inactivation and Disinfection Treatments

Although inactivation profiles were variable for each treatment, TuV and MNV were the most resistant CSV overall and therefore are the best candidates for studying the public health outcomes of norovirus infections.

Enteric bacteria promote human and mouse norovirus infection of B cells

B cells are identified as a cellular target of noroviruses and enteric bacteria as a stimulatory factor for norovirus infection, leading to the development of an in vitro infection model for human norovIRuses.

Norovirus Immunity and the Great Escape

Relationships between human herd immunity, antigenic variation, and histoblood group antigen (HBGA) recognition, which are predicted to drive the emergence of new outbreak strains that target different human populations and/or afford escape from protective herd immunity are focused on.

Attachment and entry of recombinant Norwalk virus capsids to cultured human and animal cell lines.

Binding and internalization of VLPs to cultured human and animal cell lines were studied in an attempt to identify potentially susceptible cell lines for virus propagation in vitro and to determine if early events in the replication cycle were responsible for the narrow host range and restriction of virus growth in cell culture.

Experimental Inoculation of Juvenile Rhesus Macaques with Primate Enteric Caliciviruses

The results show that ReCVs represent an alternative cell culture and animal model to study enteric calicivirus replication, pathogenesis and immunity.

Critical Review of Norovirus Surrogates in Food Safety Research: Rationale for Considering Volunteer Studies

A shift in research priorities from surrogate research to volunteer studies is essential if the authors are to identify realistic, practical, and scientifically valid processing approaches to improve food safety.

Predicting susceptibility to norovirus GII.4 by use of a challenge model involving humans.

This human challenge model should be useful for evaluating norovirus vaccines and antiviral agents and prospectively evaluated the relationship between HBGAs and norov virus infection and associated illness.

Model systems for the study of human norovirus Biology.

A summary of the recent advances in the field is aimed at highlighting how model systems have played a key role in increasing the authors' knowledge of this prevalent pathogen.
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