Rhesus Monkey Trace Amine-Associated Receptor 1 Signaling: Enhancement by Monoamine Transporters and Attenuation by the D2 Autoreceptor in Vitro

@article{Xie2007RhesusMT,
  title={Rhesus Monkey Trace Amine-Associated Receptor 1 Signaling: Enhancement by Monoamine Transporters and Attenuation by the D2 Autoreceptor in Vitro},
  author={Zhihua Xie and Susan Westmoreland and Mary E. Bahn and Guo-lin Chen and Hong Yang and Eric J. Vallender and Wei-Dong Yao and Bertha K Madras and Gregory M. Miller},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2007},
  volume={321},
  pages={116 - 127}
}
Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor that directly responds to endogenous monoamines as well as amphetamine-related psychostimulants, including methamphetamine. In the present study, we demonstrate TAAR1 mRNA and protein expression in rhesus monkey brain regions associated with monoaminergic systems, variable cellular distribution of TAAR1 in rhesus monkey brain, and TAAR1 coexpression with the dopamine transporter (DAT) in a subset of dopamine neurons in… Expand
Trace Amine-Associated Receptor 1 Is a Modulator of the Dopamine Transporter
  • Z. Xie, G. Miller
  • Biology, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
  • 2007
TLDR
Evidence that TAAR1 is involved in functional regulation of DAT is provided and suggests that TAar1 is a potentially important target for therapeutics for methamphetamine addiction. Expand
Trace amine-associated receptor 1 as a monoaminergic modulator in brain.
TLDR
The present commentary focuses on trace amine-associated receptor 1 (TAAR1) and its potential regulatory roles in brain monoaminergic systems, and discusses the recent findings that provide insights into the functional significance and biological relevance of this receptor as a modulator in brain self-regulation. Expand
Cloning, expression, and functional analysis of rhesus monkey trace amine‐associated receptor 6: Evidence for lack of monoaminergic association
TLDR
Cloning TAAR6 from the rhesus monkey and using transfected cells to investigate whether this receptor interacts with brain monoamines and a psychostimulant drug to trigger cAMP signaling or extracellular signal‐regulated kinase (ERK) phosphorylation reveals that it is unresponsive to brain monoamine levels and is not expressed in rhesUS monkey brain monoaminergic nuclei, suggesting TAAR 6 lacks direct association with brain Monoaminergic neuronal function. Expand
Modulation of Monoamine Transporters by Common Biogenic Amines via Trace Amine-Associated Receptor 1 and Monoamine Autoreceptors in Human Embryonic Kidney 293 Cells and Brain Synaptosomes
TLDR
It is deduced that TAAR1 activity inhibited uptake and promoted efflux by monoamine transporters and that monoamine autoreceptors exerted opposite effects, which provides the first evidence that common biogenic amines modulate monoamine transporter function via both TAar1 and monoamine Autoreceptor, which may balance monoaminergic activity. Expand
The Role of Biogenic Amine Transporters in Trace Amine–Associated Receptor 1 Regulation of Methamphetamine-Induced Neurotoxicity
TLDR
It is demonstrated that a functional TAAR1 protects a specific subcellular fraction of VMAT2, but not the dopamine transporter, from methamphetamine-induced effects, suggesting new directions in pharmacotherapeutic development for neurodegenerative disorders. Expand
β-Phenylethylamine Alters Monoamine Transporter Function via Trace Amine-Associated Receptor 1: Implication for Modulatory Roles of Trace Amines in Brain
  • Z. Xie, G. Miller
  • Chemistry, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
  • 2008
TLDR
Results reveal that β-PEA alters monoamine transporter function via interacting with TAAR1 but not monoamine autoreceptors, which may reveal a common mechanism by which trace amines exert modulatory effects on monoamine transporters in brain. Expand
Brain-Specific Overexpression of Trace Amine-Associated Receptor 1 Alters Monoaminergic Neurotransmission and Decreases Sensitivity to Amphetamine
TLDR
Overall, these data show that Taar1 brain overexpression causes hyposensitivity to amphetamine and alterations of monoaminergic neurotransmission and suggest that in vivo the receptor is either constitutively active and/or tonically activated by ambient levels of endogenous agonist(s). Expand
Differential Modulation of Beta-Adrenergic Receptor Signaling by Trace Amine-Associated Receptor 1 Agonists
TLDR
Molecular details of TAAR1-ligand promiscuity are pointed to and specific trace amines are identified as allosteric or orthosteric ligands of particular β-adrenergic receptor subtypes are identified. Expand
A Receptor Mechanism for Methamphetamine Action in Dopamine Transporter Regulation in Brain
  • Z. Xie, G. Miller
  • Chemistry, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
  • 2009
TLDR
Findings demonstrate a mediatory role of TAAR1 in methamphetamine action in DAT regulation and implicate this receptor as a potential target of therapeutics drugs for methamphetamine addiction. Expand
Trace Amine Associated Receptor 1 Signaling in Activated Lymphocytes
TLDR
The high levels of TAAR1 that are observed on lymphocytes are inducible and fully functional, capable of transmitting a signal likely via PKA and PKC activation following ligand binding, suggesting a possible role for TAar1 in the generation or regulation of an immune response. Expand
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References

SHOWING 1-10 OF 39 REFERENCES
Primate Trace Amine Receptor 1 Modulation by the Dopamine Transporter
TLDR
The cloning of a highly homologous TA1 from rhesus monkey and demonstration that rhTA1 receptors are activated by drugs of abuse, indicate that nonhuman primates may serve to model physiological and pharmacological TA1-mediated responses in humans. Expand
Cloning of dopamine, norepinephrine and serotonin transporters from monkey brain: relevance to cocaine sensitivity.
TLDR
The homology and functional similarity of human and monkey monoamine transporters further support the value of primates in investigating the role of monoaminetransporters in substance abuse mechanisms, neuropsychiatric disorders and development of diagnostic and therapeutic agents. Expand
Trace amines: Identification of a family of mammalian G protein-coupled receptors
  • B. Borowsky, N. Adham, +14 authors C. Gerald
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2001
TLDR
Using a degenerate PCR approach, 15 G protein-coupled receptors (GPCR) from human and rodent tissues are identified and it is demonstrated that two of these receptors bind and/or are activated by trace amines. Expand
Pharmacologic Characterization of the Cloned Human Trace Amine-Associated Receptor1 (TAAR1) and Evidence for Species Differences with the Rat TAAR1
TLDR
The TAAR1 receptor exhibits a pharmacologic profile uniquely different from those of classic monoaminergic receptors, consistent with the structural information that places them in a distinct family of receptors, and suggests the potential for development of TAAR-selective agonists and antagonists to study their physiologic roles. Expand
Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor.
TLDR
The discovery and pharmacological characterization of a rat G protein-coupled receptor that stimulates the production of cAMP when exposed to the trace amines p-tyramine, beta-phenethylamine, tryptamine, and octopamine and the discovery that amphetamines are potent rTAR1 agonists suggests that the effects of these widely used drugs may be mediated in part by this receptor as well as their previously characterized targets, the neurotransmitter transporter proteins. Expand
A Rapid Functional Assay for the Human Trace Amine-Associated Receptor 1 Based on the Mobilization of Internal Calcium
TLDR
Data indicate that the hTAAR1 retains its reported pharmacological characteristics when coupled to Gα 16, and the EC50 and Emax data obtained for known TAs are in close agreement with previous work using transient hTAar1 expression systems or a chimeric receptor. Expand
Non‐amines, drugs without an amine nitrogen, potently block serotonin transport: Novel antidepressant candidates?
TLDR
The similar affinities of non‐amines and conventional antidepressant drugs for the SERT support the view that an amine nitrogen is not essential for drugs to block serotonin transport with high affinity. Expand
Neuronal adaptation to amphetamine and dopamine: Molecular mechanisms of prodynorphin gene regulation in rat striatum
TLDR
It is demonstrated that three recently described cAMP response elements (CREs), rather than a previously reported noncanonical AP-1 site, are critical for dopamine induction of the prodynorphin gene in striatal neurons. Expand
Dopamine D1 receptors characterized with [3H]SCH 23390. Solubilization of a guanine nucleotide-sensitive form of the receptor.
TLDR
Results suggest that the same guanine nucleotide-dopamine D1 receptor complex formed in membranes is stable to solubilization and confers agonist high affinity binding in soluble preparations, and contrast with those reported on the digitonin-solubilized dopamine D2 receptor. Expand
MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: implications for MDMA-induced neurotoxicity and treatment
TLDR
The affinity of ecstasy for the human SERT in transfected cells does not clarify the apparent selective toxicity of MDMA for serotonin neurons, although conceivably, its higher efficacy for stimulating 5-HT release may be a distinguishing factor. Expand
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