Rhes and AGS1/Dexras1 affect signaling by dopamine D1 receptors through adenylyl cyclase.


The GTP binding proteins Rhes and AGS1/Dexras1 define a subfamily of the Ras superfamily and have been shown to affect signaling by G-protein-coupled receptors. We tested the effects of both proteins at an early stage of signaling by dopamine receptors, activation of adenylyl cyclase. Rhes decreased dopamine D1 receptor agonist-stimulated cAMP accumulation… (More)
DOI: 10.1002/jnr.22604


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