Rheological study of the mixture of acetaminophen and polyethylene oxide for hot-melt extrusion application.

Abstract

There is a growing interest of extrusion drug and polymer together to manufacture various solid dosages. In those cases, the drug's release profiles are greatly affected by the miscibility of two materials. The goal of this study is to test the drug's solubility in molten polymer and obtain the mixture's rheological properties for the purpose of optimizing… (More)
DOI: 10.1016/j.ejpb.2011.03.013

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