Rheological characterization of xanthan gum and hydroxypropylmethyl cellulose with respect to controlled-release drug delivery.

@article{Talukdar1996RheologicalCO,
  title={Rheological characterization of xanthan gum and hydroxypropylmethyl cellulose with respect to controlled-release drug delivery.},
  author={M M Talukdar and Inge Vinckier and Paula Moldenaers and Renaat Kinget},
  journal={Journal of pharmaceutical sciences},
  year={1996},
  volume={85 5},
  pages={537-40}
}
It has been observed previously that xanthan gum (XG) and hydroxypropylmethyl cellulose (HPMC) show different drug release behavior. In order to clarify these findings, the rheological properties of both polymers have been determined by oscillatory as well as by steady shear measurements. Aqueous solutions of 4 and 7% (w/w) polymer have been used to simulate the outer surface of a hydrated tablet. The dynamic moduli, i.e., storage modulus (G') and loss modulus (G") of the two polymers have been… CONTINUE READING