Rheological, mechanical and mucoadhesive properties of thermoresponsive, bioadhesive binary mixtures composed of poloxamer 407 and carbopol 974P designed as platforms for implantable drug delivery systems for use in the oral cavity.

@article{Jones2009RheologicalMA,
  title={Rheological, mechanical and mucoadhesive properties of thermoresponsive, bioadhesive binary mixtures composed of poloxamer 407 and carbopol 974P designed as platforms for implantable drug delivery systems for use in the oral cavity.},
  author={D. S. Jones and Marcos Luciano Bruschi and Osvaldo de Freitas and Maria Palmira Daflon Gremi{\~a}o and Elza Helena Guimar{\~a}es Lara and Gavin P Andrews},
  journal={International journal of pharmaceutics},
  year={2009},
  volume={372 1-2},
  pages={49-58}
}
This study described the formulation and characterisation of the viscoelastic, mechanical and mucoadhesive properties of thermoresponsive, binary polymeric systems composed of poloxamer (P407) and poly(acrylic acid, C974P) that were designed for use as a drug delivery platform within the oral cavity. Monopolymeric and binary polymeric formulations were prepared containing 10, 15 and 20% (w/w) poloxamer (407) and 0.10-0.25% (w/w) poly(acrylic acid, 934P). The flow rheological and viscoelastic… CONTINUE READING

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