Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells

@article{Im2002RhebII,
  title={Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells},
  author={Edward Im and Friederike C. von Lintig and Jeffrey Chen and Shunhui Zhuang and Wansong Qui and Shoaib Chowdhury and Paul F Worley and Gerry R. Boss and Renate B Pilz},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={6356-6365}
}
Rheb (Ras homolog enriched in brain) is a member of the Ras family of proteins, and is in the immediate Ras/Rap/Ral subfamily. We found in three different mammalian cell lines that Rheb was highly activated, to levels much higher than for Ras or Rap 1, and that Rheb's activation state was unaffected by changes in growth conditions. Rheb's high activation was not secondary to unique glycine to arginine, or glycine to serine substitutions at positions 14 and 15, corresponding to Ras residues 12… CONTINUE READING
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