Rheb and Rags come together at the lysosome to activate mTORC1.

@article{Groenewoud2013RhebAR,
  title={Rheb and Rags come together at the lysosome to activate mTORC1.},
  author={M. J. Groenewoud and F. Zwartkruis},
  journal={Biochemical Society transactions},
  year={2013},
  volume={41 4},
  pages={
          951-5
        }
}
  • M. J. Groenewoud, F. Zwartkruis
  • Published 2013
  • Biology, Medicine
  • Biochemical Society transactions
  • mTORC1 (mammalian target of rampamycin complex 1) is a highly conserved protein complex regulating cell growth and metabolism via its kinase mTOR (mammalian target of rapamycin). The activity of mTOR is under the control of various GTPases, of which Rheb and the Rags play a central role. The presence of amino acids is a strict requirement for mTORC1 activity. The heterodimeric Rag GTPases localize mTORC1 to lysosomes by their amino-acid-dependent interaction with the lysosomal Ragulator complex… CONTINUE READING
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