Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.

@article{Inoki2003RhebGI,
  title={Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.},
  author={Ken Inoki and Yong Li and Tian Xu and Kun-Liang Guan},
  journal={Genes & development},
  year={2003},
  volume={17 15},
  pages={
          1829-34
        }
}
Tuberous sclerosis complex (TSC) is a genetic disease caused by mutation in either TSC1 or TSC2. The TSC1 and TSC2 gene products form a functional complex and inhibit phosphorylation of S6K and 4EBP1. These functions of TSC1/TSC2 are likely mediated by mTOR. Here we report that TSC2 is a GTPase-activating protein (GAP) toward Rheb, a Ras family GTPase. Rheb stimulates phosphorylation of S6K and 4EBP1. This function of Rheb is blocked by rapamycin and dominant-negative mTOR. Rheb stimulates the… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 816 CITATIONS

Modulation of the secretory pathway by amino-acid starvation

VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Hydrogen sulfide promotes angiogenesis by downregulating miR-640 via the VEGFR2/mTOR pathway.

  • American journal of physiology. Cell physiology
  • 2016
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Autophagy in malignant transformation and cancer progression.

  • The EMBO journal
  • 2015
VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2003
2019

CITATION STATISTICS

  • 113 Highly Influenced Citations

  • Averaged 67 Citations per year over the last 3 years

Similar Papers

Loading similar papers…