Rheb GTPase controls apoptosis by regulating interaction of FKBP38 with Bcl-2 and Bcl-XL.

Abstract

FKBP38 is a member of the family of FK506-binding proteins that acts as an inhibitor of the mammalian target of rapamycin (mTOR). The inhibitory action of FKBP38 is antagonized by Rheb, an oncogenic small GTPase, which interacts with FKBP38 and prevents its association with mTOR. In addition to the role in mTOR regulation, FKBP38 is also involved in binding… (More)
DOI: 10.1074/jbc.M109.092353

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@article{Ma2010RhebGC, title={Rheb GTPase controls apoptosis by regulating interaction of FKBP38 with Bcl-2 and Bcl-XL.}, author={Dongzhu Ma and Xiaochun Bai and Huafei Zou and Yumei Lai and Yu Jiang}, journal={The Journal of biological chemistry}, year={2010}, volume={285 12}, pages={8621-7} }