Rheb Binds and Regulates the mTOR Kinase

@article{Long2005RhebBA,
  title={Rheb Binds and Regulates the mTOR Kinase},
  author={Xiaomeng Long and Yenshou Lin and Sara Ortiz-Vega and Kazuyoshi Yonezawa and Joseph Avruch},
  journal={Current Biology},
  year={2005},
  volume={15},
  pages={702-713}
}
BACKGROUND The target of rapamycin (TOR), in complex with the proteins raptor and LST8 (TOR complex 1), phosphorylates the p70S6K and 4E-BP1 to promote mRNA translation. Genetic evidence establishes that TOR complex activity in vivo requires the small GTPase Rheb, and overexpression of Rheb can rescue TOR from inactivation in vivo by amino-acid withdrawal. The Tuberous Sclerosis heterodimer (TSC1/TSC2) functions as a Rheb GTPase activator and inhibits TOR signaling in vivo. RESULTS Here, we… CONTINUE READING
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Novel modes of mTORC1 regulation by amino acids

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MCRS1 binds and couples Rheb to amino acid-dependent mTORC1 activation.

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