Rhamnus cathartica (Buckthorn) Hepatocellular Toxicity in Mice

@article{Lichtensteiger1997RhamnusC,
  title={Rhamnus cathartica (Buckthorn) Hepatocellular Toxicity in Mice},
  author={Carol A. Lichtensteiger and Nancy A. Johnston and Val Richard Beasley},
  journal={Toxicologic Pathology},
  year={1997},
  volume={25},
  pages={449 - 452}
}
The toxicity of the plant Rhamnus cathartica was assessed in mice after the plant was identified as a potential cause of an idiopathic neurologic disease in horses. Another member of the Rhamnaceae family, Karwinskia humboldtiana, is neurotoxic to mammals and birds and can induce hepatic degeneration and necrosis. To investigate the toxicity of R. cathartica, a 34-day feeding trial in mice was conducted using a complete rodent diet with 0, 5, or 25% added R. cathartica. No clinical signs or… Expand
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