Rhabdovirus-based vectors with human immunodeficiency virus type 1 (HIV-1) envelopes display HIV-1-like tropism and target human dendritic cells.

@article{Foley2002RhabdovirusbasedVW,
  title={Rhabdovirus-based vectors with human immunodeficiency virus type 1 (HIV-1) envelopes display HIV-1-like tropism and target human dendritic cells.},
  author={Heather D. Foley and M Jes{\'u}s {\'A}lvarez Otero and Jan Marc Orenstein and Roger J. Pomerantz and Matthias J Schnell},
  journal={Journal of virology},
  year={2002},
  volume={76 1},
  pages={19-31}
}
We describe replication-competent, vaccine strain-based rabies viruses (RVs) that lack their own single glycoprotein and express, instead, a chimeric RV-human immunodeficiency virus type 1 (HIV-1) envelope protein composed of the ectodomain and transmembrane domains of HIV-1 gp160 and the cytoplasmic domain of RV G. The envelope proteins from both X4 (NL4-3)- and R5X4 (89.6)-tropic HIV-1 strains were utilized. These recombinant viruses very closely mimicked an HIV-1- like tropism, as indicated… CONTINUE READING