Rhabdomyosarcomas utilize developmental, myogenic growth factors for disease advantage: a report from the Children's Oncology Group.

@article{Blandford2006RhabdomyosarcomasUD,
  title={Rhabdomyosarcomas utilize developmental, myogenic growth factors for disease advantage: a report from the Children's Oncology Group.},
  author={Mary C Blandford and F. G. Barr and James C. Lynch and Robert Lor Randall and Stephen J. Qualman and Charles Keller},
  journal={Pediatric blood & cancer},
  year={2006},
  volume={46 3},
  pages={329-38}
}
BACKGROUND Unresectable or metastatic disease represents the greatest obstacle to cure for children with rhabdomyosarcoma. In this study we sought to identify gene expression signatures of advanced stage and progressive disease. PROCEDURE Using oligonucleotide gene expression analysis for a focused set of 60 genes, we analyzed the myogenic expression profiles of 89 rhabdomyosarcomas from the Intergroup Rhabdomyosarcoma Study-IV. RESULTS While the expression profile of rhabdomyosarcomas… CONTINUE READING

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Real - time reverse transcriptase polymerase chain reaction ( RT - PCR ) of an independent data set suggested that autocrine growth signaling , if present , is not regulated in a simple manner at the transcriptional level .
Real - time reverse transcriptase polymerase chain reaction ( RT - PCR ) of an independent data set suggested that autocrine growth signaling , if present , is not regulated in a simple manner at the transcriptional level .
Real - time reverse transcriptase polymerase chain reaction ( RT - PCR ) of an independent data set suggested that autocrine growth signaling , if present , is not regulated in a simple manner at the transcriptional level .
Real - time reverse transcriptase polymerase chain reaction ( RT - PCR ) of an independent data set suggested that autocrine growth signaling , if present , is not regulated in a simple manner at the transcriptional level .
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