Rhabdomyolysis: a review, with emphasis on the pediatric population

@article{Elsayed2010RhabdomyolysisAR,
  title={Rhabdomyolysis: a review, with emphasis on the pediatric population},
  author={Essam Elsayed and Robert F. Reilly},
  journal={Pediatric Nephrology},
  year={2010},
  volume={25},
  pages={7-18}
}
Rhabdomyolysis is a common clinical syndrome and accounts for 7% of all cases of acute kidney injury (AKI) in the USA. It can result from a wide variety of disorders, such as trauma, exercise, medications and infection, but in the pediatric population, infection and inherited disorders are the most common causes of rhabdomyolysis. Approximately half of patients with rhabdomyolysis present with the triad of myalgias, weakness and dark urine. The clinical suspicion, especially in the setting of… 
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A diagnostic algorithm for rhabdomyolysis is proposed, which is aimed at preserving renal function, resolving compartment syndrome, restoring metabolic derangements, and volume replacement in patients with acute renal failure.
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TLDR
The classic triad of symptoms of rhabdomyolysis includes myalgia, weakness and dark urine are not always presented in children, and the prognosis of r Habdomyolynsis was good with appropriate management.
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TLDR
In children, infection was the most common cause of rhabdomyolysis, and in severe cases, especially in patients with underlying kidney disease, hemodialysis may be necessary in the present study.
Can McArdle disease be induced by infection associated with rhabdomyolysis case report?
  • A. Ghavidel
  • Medicine, Biology
    Journal of Analytical Research in Clinical Medicine
  • 2018
TLDR
Rhabdomyolysis may develop among individuals with abnormal muscles as in congenital diseases of glycogenolysis, glycolysis, purine, and lipid metabolism, which prevents physicians from administrating certain drugs in patients with MD.
McArdle disease: a “pediatric” disorder presenting in an adult with acute kidney injury
TLDR
A case of an adult patient presenting with acute rhabdomyolysis secondary to McArdle disease, a genetic disease causing defective glycogenolysis is reported, highlighting the importance of recognizing the potential of undiagnosed “pediatric” disorders in adulthood.
Rhabdomyolysis with different etiologies in childhood
TLDR
It is important to distinguish the sporadic and recurrent rhabdomyolysis cases from each other and to follow up more regardful and attentive.
The role of diagnostic and prognostic factors
TLDR
Rhabdomyolysis has characteristic clinical, laboratory and radiologic features, but does require a high index of suspicion so that the diagnosis would not be missed, and the sensitivity and specificity of the various characteristics are discussed.
Rhabdomyolysis: Revisited
TLDR
The mortality rate ranges from 10% to up to 50% with severe AKI, so high index of suspicion and screening should be in care plan of seriously ill patients at risk for RML.
Acute kidney injury in pediatric patients with rhabdomyolysis
TLDR
Compared with the non-AKI group, the AKI group showed higher levels of peak creatinine kinase and myoglobin, without statistical significance, which indicates children with underlying diseases are more vulnerable to rhabdomyolysis-induced AKI.
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References

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TLDR
Exogenous toxins were the most common cause of rhabdomyolysis, with illicit drugs, alcohol, and prescribed drugs responsible for 46%.
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TLDR
A high index of suspicion, early recognition, and adequate treatment will result in an excellent prognosis of drug-induced rhabdomyolysis.
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TLDR
The causes, clinical presentation, and prevalence of acute renal failure in pediatric rhabdomyolysis with the published data for adults are compared, and the relationship of acute kidney failure with treatment modalities such as fluid and bicarbonate administration is explored.
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Rhabdomyolysis is a common condition in which injury to skeletal muscle results in leakage of the contents of myocytes into extravascular uid and, if severe enough, passage of suf®cient myoglobin
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TLDR
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TLDR
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