Rhabdomyolysis: Review of the literature

  title={Rhabdomyolysis: Review of the literature},
  author={Rodi Zutt and A. van der Kooi and Gabor E. Linthorst and Ronald J. A. Wanders and M. Visser},
  journal={Neuromuscular Disorders},

Figures and Tables from this paper

Spectrum of rhabdomyolysis in an acute hospital
Rhabdomyolysis is a common and a serious clinical condition across many specialties in an acute hospital that would likely benefit from nephrology involvement should acute kidney injury supervene.
Rhabdomyolysis: Revisited
The mortality rate ranges from 10% to up to 50% with severe AKI, so high index of suspicion and screening should be in care plan of seriously ill patients at risk for RML.
Rhabdomyolysis and Acute Kidney Injury Associated With Terbinafine Use: A Case Report
A previously healthy 22-year-old male presented with nausea, vomiting, and dark urine after taking terbinafine 250 mg daily for a tinea infection for 9 days and developed severe rhabdomyolysis with a serum creatine kinase (CK) of >100 000 U/L as well as anuric acute kidney injury.
Rhabdomyolysis after Concomitant Use of Statins and Antibiotics
This clinical and laboratory syndrome typically presents with the triad of myalgia, muscle weakness, and urin darkness, but sometimes rhabdomyolysis can be totally asymptomatic.
Rhabdomyolysis caused by exercise
A case report of a patient with rhabdomyolysis with severe elevation of muscle enzymes and secondary acute kidney injury who was subsequently documented (initial Total CK 189,000 u/L) after extreme physical activity (CrossFit), who developed multiple complications and the need for support in the Intensive Care Unit (ICU) with satisfactory outcome.
Clinical spectrum of rhabdomyolysis presented to pediatric emergency department
The classic triad of symptoms of rhabdomyolysis includes myalgia, weakness and dark urine are not always presented in children, and the prognosis of r Habdomyolynsis was good with appropriate management.
Mild Creatine Kinase Elevations Do Not Necessarily Reflect Rhabdomyolysis.
The authors concluded that clinicians should be aware of this life-threatening manifestation of COVID-19 so that prompt and appropriate interventions can be performed and which drugs the patient received before the onset of rhabdomyolysis.


Rhabdomyolysis: a review, with emphasis on the pediatric population
Early recognition is important to prevent AKI through the use of aggressive hydration and novel therapies may be developed with the better understanding of the pathophysiology and genetics of rhabdomyolysis.
Rhabdomyolysis: a review of the literature.
  • F. Khan
  • Medicine
    The Netherlands journal of medicine
  • 2009
The objective of this review is to describe the aetiological spectrum and pathophysiology of rhabdomyolysis, the clinical and biological consequences of this syndrome and to provide an appraisal of the current data available in order to facilitate the prevention, early diagnosis and prompt management of this condition.
Rhabdomyolysis in the Intensive Care Unit
Early, aggressive resuscitation with either normal saline or lactated Ringer’s solution to maintain an adequate urine output is the most important intervention in preventing the development of acute renal failure.
Rhabdomyolysis: An Evaluation of 475 Hospitalized Patients
Exogenous toxins were the most common cause of rhabdomyolysis, with illicit drugs, alcohol, and prescribed drugs responsible for 46%.
Acute Pediatric Rhabdomyolysis
A retrospective review of children admitted to the authors' institution during an 8-year period in whom rhabdomyolysis was recognized as a complication during their hospital stay found that renal failure was the most frequent complication, occurring in 42% of cases.
The clinical and biochemical features of acute renal failure due to rhabdomyolysis.
Clinical features of muscle damage were often absent and so the possibility of rhabdomyolysis should be considered in appropriate settings if the diagnosis is to be made early enough to administer treatment that may prevent ARF and the consequences of the compartment syndrome.
Rhabdomyolysis: Has many causes, including statins, and may be fatal
The dramatic title–Rhabdomyolysis: the hidden killer–given to a recent review of this condition emphasised that dissolution of striated muscle fibres, with leakage of muscle enzymes, myoglobin,
Rhabdomyolysis and acute renal failure in children
It is suggested that ARF is more likely to develop in the presence of dehydration, metabolic acidosis, or severe muscle damage, or with multiple organ failure in children with acute rhabdomyolysis.
Rhabdomyolysis: historical background, clinical, diagnostic and therapeutic features
Abstract Rhabdomyolysis, a term used to describe the rapid breakdown of striated muscle, is characterized by rupture and necrosis of muscle fibers. This process results in the release of cell
Rhabdomyolysis and myohemoglobinuric acute renal failure.
  • R. Zager
  • Medicine
    Kidney international
  • 1996
How muscle necrosis can negatively impact the kidney, potentially culminating in tubular necrosis and ARF is discussed, to review current and possible future pharmacologic approaches for the management of this dramatic and often life threatening "myo-renal syndrome".