Rhabdomyolysis, myoglobinuria and exercise.

  title={Rhabdomyolysis, myoglobinuria and exercise.},
  author={C. J. Robertson Milne},
  journal={Sports medicine},
  volume={6 2},
Muscle membrane injury is a predictable consequence of extreme exertion. The risk is compounded if an untrained individual performs eccentric exercise in a hot environment, or there is any preceding infectious disease, drug ingestion or an underlying metabolic disorder. Once the integrity of the membrane is breached, a constellation of physiological changes follows. Cell contents leak out and extracellular components leak in. Muscle pain and weakness ensue. Myoglobin is but one substance that… CONTINUE READING