Rh(III)-catalyzed cascade oxidative olefination/cyclization of picolinamides and alkenes via C-H activation.

Abstract

Rh(III)-catalyzed cascade oxidative alkenylation/cyclization of picolinamides and alkenes to furnish pyrido pyrrolone derivatives is described, in which three C-H bonds and one N-H bond broke, while one C-C bond and one C-N bond formed. The reaction proceeded with high yield and high regioselectivity and stereoselectivity. Moreover, copper acetate can also be used in catalytic amounts with O2 serving as the terminal oxidant.

DOI: 10.1021/ol501275r

Cite this paper

@article{Cai2014RhIIIcatalyzedCO, title={Rh(III)-catalyzed cascade oxidative olefination/cyclization of picolinamides and alkenes via C-H activation.}, author={Shangjun Cai and Chao Chen and Peng Shao and Chanjuan Xi}, journal={Organic letters}, year={2014}, volume={16 11}, pages={3142-5} }