Rgs13 Constrains Early B Cell Responses and Limits Germinal Center Sizes

@article{Hwang2013Rgs13CE,
  title={Rgs13 Constrains Early B Cell Responses and Limits Germinal Center Sizes},
  author={Il-Young Hwang and Kyung-Sun Hwang and Chung Park and K. Harrison and J. Kehrl},
  journal={PLoS ONE},
  year={2013},
  volume={8}
}
Germinal centers (GCs) are microanatomic structures that develop in secondary lymphoid organs in response to antigenic stimulation. Within GCs B cells clonally expand and their immunoglobulin genes undergo class switch recombination and somatic hypermutation. Transcriptional profiling has identified a number of genes that are prominently expressed in GC B cells. Among them is Rgs13, which encodes an RGS protein with a dual function. Its canonical function is to accelerate the intrinsic GTPase… Expand
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