Rgs 2 gene polymorphisms as modulators of anxiety in humans?

  title={Rgs 2 gene polymorphisms as modulators of anxiety in humans?},
  author={A. Leygraf and Christa Hohoff and Christine Freitag and Saffron A. G. Willis-Owen and Petra Krakowitzky and J{\"u}rgen Fritze and Petra Franke and Borwin Bandelow and Rolf Fimmers and Jonathan Flint and J{\"u}rgen Deckert},
  journal={Journal of Neural Transmission},
Rgs2 (regulator of G-protein signalling 2) gene recently was reported as a quantitative trait gene for anxious behaviour in mice and male Rgs2 knockout mice have been shown to be more anxious than wildtype mice. Therefore we investigated four non-coding single nucleotide polymorphisms in a sample of 173 patients with panic disorder and 173 matched controls of German descent. At the genotype level all four SNPs were associated with panic disorder (p = 0.02–0.05). At the haplotype level the… CONTINUE READING
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