Rfx6 Maintains the Functional Identity of Adult Pancreatic β Cells

  title={Rfx6 Maintains the Functional Identity of Adult Pancreatic β Cells},
  author={Julie Piccand and Perrine Strasser and David J Hodson and Aline Meunier and Tao Ye and C{\'e}line Keime and Marie-Christine Birling and Guy A Rutter and G{\'e}rard Gradwohl},
  booktitle={Cell reports},
Increasing evidence suggests that loss of β cell characteristics may cause insulin secretory deficiency in diabetes, but the underlying mechanisms remain unclear. Here, we show that Rfx6, whose mutation leads to neonatal diabetes in humans, is essential to maintain key features of functionally mature β cells in mice. Rfx6 loss in adult β cells leads to glucose intolerance, impaired β cell glucose sensing, and defective insulin secretion. This is associated with reduced expression of core… CONTINUE READING
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