Reye's syndrome and salicylate use.

@article{Starko1980ReyesSA,
  title={Reye's syndrome and salicylate use.},
  author={Karen M. Starko and C. George Ray and L B Dominguez and Wayne Stromberg and D F Woodall},
  journal={Pediatrics},
  year={1980},
  volume={66 6},
  pages={
          859-64
        }
}
During an outbreak of influenza A, seven patients with Reye's syndrome and 16 ill classmate control subjects were evaluated for characteristics of the patients' prodromal illness and the control subjects illness and for medication usage. Patients during the prodrome and control subjects had similar rates of sore throat, coryza, cough, headache, and gastrointestinal complaints except for documented fever which occurred significantly more often in patients than in control subjects (P = .05… 

Reye's syndrome and salicylate use, by Karen M. Starko, MD, et al, Pediatrics, 1980;66:859-864; and National patterns of aspirin use and Reye syndrome reporting, United States, 1980 to 1985, by Janet B. Arrowsmith et al, Pediatrics, 1987;79:858-863.

It is postulated that salicylate, operating in a dose-dependent manner, possibly potentiated by fever, represents a primary causative agent of Reye's syndrome.

Reye's Syndrome and Medication Use

Ninety-seven Reye's syndrome cases in Ohio children with onsets from December 1978 through March 1980 were studied for medication use during their pre-RS illness, and no relationship was found between dosage and stage of RS encephalopathy.

Preadmission antipyretics in Reye's syndrome.

The findings suggested that an association between Reye's syndrome and preadmission aspirin may exist in some children.

Aspirin and Reye's syndrome.

  • W. P. Glezen
  • Medicine
    American journal of diseases of children
  • 1982
A series of case-control studies have been reported that suggest that the administration of aspirin to children during the prodromal viral infection increases the risk for development of Reye's syndrome.

Reye's syndrome: a case control study of medication use and associated viruses in Australia.

A lack of association between aspirin ingestion and the development of Reye's syndrome was confirmed and influenza A or B viruses were recovered from any patient.

Salicylates and Reye's syndrome: epidemiologic data as a basis of action.

Anecdotal observations that what the authors now know as Reye's syndrome (RS) was associated with ingestion of salicylates preceded the definition of this syndrome, and a variety of etiologic hypotheses have been entertained, including insecticides and related chemicals, aflatoxins, and salicYLates.

Reye syndrome or side-effects of anti-emetics?

By analysing two patients initially diagnosed as Reye syndrome evidence is given that in some patients considered as having Reye syndrome, the syndrome is an escalation of symptoms due to viral

Reye's syndrome and aspirin. Evidence for a dose-response effect.

The relationship between the development of Reye's syndrome and the dose of aspirin received during the antecedent respiratory or chickenpox illness was analyzed and case-patients were found to have received greater average daily and maximum daily doses of aspirin.

Reye ' s Syndrome Arising from the Treatment of Kawasaki Disease

Paediatricians and emergency physicians can consider using a low dose of aspirin (3-5 mg/kg) as maintenance therapy, discontinuing aspirin for a short period or replace it with dipyridamole during influenza or varicella epidemics, and having a high index of suspicion of Reye's syndrome in patients with Kawasaki disease.
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