Rexpression of HLA class I antigens and restoration of antigen-specific CTL response in melanoma cells following 5-aza-2'-deoxycytidine treatment.

@article{Serrano2001RexpressionOH,
  title={Rexpression of HLA class I antigens and restoration of antigen-specific CTL response in melanoma cells following 5-aza-2'-deoxycytidine treatment.},
  author={A. R. M. Serrano and Silvia Tanzarella and Ilaria Lionello and R E M{\'e}ndez and Catia Traversari and Francisco Javier Montes Ruiz-Cabello and Federico Garrido},
  journal={International journal of cancer},
  year={2001},
  volume={94 2},
  pages={243-51}
}
Cell surface expression of HLA class I/peptide complexes on tumor cells is a key step in the generation of T-cell-based immune responses. Several genetic defects underlying the lack of HLA class I expression have been characterized. Here we describe another molecular mechanism that accounts for the complete absence of HLA class I molecule expression in a tumor line (MSR3-mel) derived from a melanoma patient. Hypermethylation of the MSR3-mel DNA, specifically of HLA-A and -B genes, was… CONTINUE READING