Rexinoid-induced expression of IGFBP-6 requires RARbeta-dependent permissive cooperation of retinoid receptors and AP-1.

Abstract

The synthetic rexinoid bexarotene (Targretin, LGD1069) inhibits the formation of both estrogen receptor-negative and estrogen receptor-positive breast cancer in preclinical models and controls the expression of growth-regulatory biomarkers, such as IGFBP-6 (insulin-like growth factor-binding protein 6), RARbeta, or cyclin D1. In this study, we identified a… (More)
DOI: 10.1074/jbc.M804721200

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@article{Uray2009RexinoidinducedEO, title={Rexinoid-induced expression of IGFBP-6 requires RARbeta-dependent permissive cooperation of retinoid receptors and AP-1.}, author={Iv{\'a}n P. Uray and Qiang Shen and Hye-Sook Seo and Heetae Kim and William W. Lamph and R Bissonnette and Powel H. Brown}, journal={The Journal of biological chemistry}, year={2009}, volume={284 1}, pages={345-53} }