Rex1/Zfp42 is dispensable for pluripotency in mouse ES cells

  title={Rex1/Zfp42 is dispensable for pluripotency in mouse ES cells},
  author={Shinji Masui and Satoshi Ohtsuka and Rika Yagi and Kadue Takahashi and Minoru S. H Ko and Hitoshi Niwa},
  journal={BMC Developmental Biology},
  pages={45 - 45}
Rex1/Zfp42 has been extensively used as a marker for the undifferentiated state of pluripotent stem cells. However, its function in pluripotent stem cells including embryonic stem (ES) cells remained unclear although its involvement in visceral endoderm differentiation in F9 embryonal carcinoma (EC) cells was reported. We showed the function of Rex1 in mouse ES cells as well as in embryos using the conventional gene targeting strategy. Our results clearly indicated that Rex1 function is… CONTINUE READING
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