Rewriting yeast central carbon metabolism for industrial isoprenoid production

  title={Rewriting yeast central carbon metabolism for industrial isoprenoid production},
  author={Adam L. Meadows and Kristy M. Hawkins and Yoseph Tsegaye and Eugene Antipov and Youngnyun Kim and Lauren Raetz and Robert H. Dahl and Anna Tai and Tina Mahatdejkul-Meadows and Lan Xu and Lishan Zhao and Madhukar S. Dasika and Abhishek Murarka and Jacob Lenihan and Diana Eng and Joshua S. Leng and Chi-Li Liu and Jared W. Wenger and Hanxiao Jiang and Lily C Chao and Patrick Westfall and Jefferson Lai and Savita Ganesan and Peter Jackson and Robert Mans and Darren Platt and Christopher D. Reeves and Poonam R. Saija and Gale Wichmann and Victor F. Holmes and Kirsten Benjamin and Paul W. Hill and Timothy S. Gardner and Annie E. Tsong},
A bio-based economy has the potential to provide sustainable substitutes for petroleum-based products and new chemical building blocks for advanced materials. We previously engineered Saccharomyces cerevisiae for industrial production of the isoprenoid artemisinic acid for use in antimalarial treatments. Adapting these strains for biosynthesis of other isoprenoids such as β-farnesene (C15H24), a plant sesquiterpene with versatile industrial applications, is straightforward. However, S… CONTINUE READING
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