Rewiring the keyboard: evolvability of the genetic code

@article{Knight2001RewiringTK,
  title={Rewiring the keyboard: evolvability of the genetic code},
  author={R. Knight and S. Freeland and L. Landweber},
  journal={Nature Reviews Genetics},
  year={2001},
  volume={2},
  pages={49-58}
}
The genetic code evolved in two distinct phases. First, the 'canonical' code emerged before the last universal ancestor; subsequently, this code diverged in numerous nuclear and organelle lineages. Here, we examine the distribution and causes of these secondary deviations from the canonical genetic code. The majority of non-standard codes arise from alterations in the tRNA, with most occurring by post-transcriptional modifications, such as base modification or RNA editing, rather than by… Expand

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